منابع مشابه
P-48: Nicotine Alters Both Somatic and Germ Cells in Adult Mouse Testis
Background: Nicotine as a toxic agent in cigarette has detrimental effects on reproduction. The aim of this study was to evaluate effects of of nicotine on germ and somatic cells in adult mouse testis. Materials and Methods: Male mice were divided into four groups. Group A or controls, groups of B, C and D were treated with nicotine intraperitoneally in doses of 0.1, 0.2 and 0.4 mg/100 g body w...
متن کاملIn Vitro Spermatogenesis in Explanted Adult Mouse Testis Tissues
Research on in vitro spermatogenesis is important for elucidating the spermatogenic mechanism. We previously developed an organ culture method which can support spermatogenesis from spermatogonial stem cells up to sperm formation using immature mouse testis tissues. In this study, we examined whether it is also applicable to mature testis tissues of adult mice. We used two lines of transgenic m...
متن کاملWt1 dictates the fate of fetal and adult Leydig cells during development in the mouse testis.
Wilms' tumor 1 (Wt1) is a tumor suppressor gene encoding ∼24 zinc finger transcription factors. In the mammalian testis, Wt1 is expressed mostly by Sertoli cells (SCs) involved in testis development, spermatogenesis, and adult Leydig cell (ALC) steroidogenesis. Global knockout (KO) of Wt1 is lethal in mice due to defects in embryogenesis. Herein, we showed that Wt1 is involved in regulating fet...
متن کاملphylogeography and genetic diversity of the lesser mouse- eared bat (myotis blythii) in iran
in current study, 63 samples of bat populations collected from differ regions were used for evaluating the geographic variations. twenty cranial and dental characters for traditional morphometric and landmarks method on the ventral, dorsal skull and mandible for geometry morphometric studies were used. statistical analyses of traditional morphometric and geometry morphometric data indicated low...
Sertoli Cells Maintain Leydig Cell Number and Peritubular Myoid Cell Activity in the Adult Mouse Testis
The Sertoli cells are critical regulators of testis differentiation and development. In the adult, however, their known function is restricted largely to maintenance of spermatogenesis. To determine whether the Sertoli cells regulate other aspects of adult testis biology we have used a novel transgenic mouse model in which Amh-Cre induces expression of the receptor for Diphtheria toxin (iDTR) s...
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ژورنال
عنوان ژورنال: Molecular Reproduction and Development
سال: 2016
ISSN: 1040-452X
DOI: 10.1002/mrd.22745